Similarly to OPTN and SQSTM1, also VCP and PFN1 share common roles in autophagic degradation raising the hypothesis of a common pathogenic mechanism affecting the formation and clearance of misfolded proteins in PDB, ALS and, more generally, in lysosomal storage diseases (Hocking et al., 2012; Lieberman et al., 2012; Vallet and Ralston, 2016b). The gene discussed is PFN1; the disease is amyotrophic lateral sclerosis.