In keeping with this hypothesis a N357S genetic variant of TIA1 gene (encoding for a key component of cytosolic stress granules) has been shown to interact with SQSTM1 mutations to cause distal myopathy, whereas both SQSTM1 mutation and the N357S genetic variant alone do not cause myopathy (Lee et al., 2018). Here, SQSTM1 is linked to distal myopathy.