EGF and neoplasm: At early stages of transcoelomic metastasis of mouse epithelial ovarian cancer, M2 macrophage-like TAMs formed spheroids and secreted EGF, which upregulated αMβ2 integrin on TAMs and ICAM-1 on tumor cells to enhance association between tumor cells and TAMs, then to support tumor cell proliferation and migration (Yin et al., 2016).