Moreover, hyaluronic acid secreted by ovarian cancer cells promotes plasma membrane cholesterol efflux in TAMs via binding to CD44, which enhances IL-4 receptor signaling in vitro and in vivo associated with reduced intracellular cholesterol, finally promoting the expression of the typical M2 marker Arg1 while inhibiting proinflammatory IL-12 expression (Goossens et al., 2019). The gene discussed is ARG1; the disease is ovarian cancer.