YTHDF2 and colorectal cancer: For example, the expression of M6A “writer” protein methyltransferase-like 14 (METTL14) is downregulated in colorectal cancer, and it has been found that XIST is downregulated by METTL14 in a YTHDF2-dependent way, which is responsible for inhibiting the growth of colorectal cancer (Yang et al., 2020).