Additionally, Jayappa et al suggested that the activation of the NF-κB pathway in MCL cells could lead to an enhanced expression of the anti-apoptotic proteins Bcl-xL and Mcl-1, decreasing the dependency of tumor cells on Bcl-2 and thus their sensitivity to Venetoclax (Jayappa et al., 2017). The gene discussed is BCL2; the disease is mantle cell lymphoma.