B-Cell Receptor (BCR)-linked survival signaling cascades, such as Phosphatidylinositide 3-Kinases/AKT (PI3K/AKT), mammalian Target Of Rapamycin (mTOR), Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-kB), the Extracellular signal-Regulated Kinase (ERK) cascades and the Bcl-2 family of apoptosis regulators, are chronic active in MCL and enhance tumor proliferation, facilitating evasion of apoptosis. The gene discussed is NFKB1; the disease is mantle cell lymphoma.