In diffuse large B-cell lymphomas, PARP9 functions as a co-repressor of the IFNγ-STAT1-IRF1 axis to inhibit apoptosis and as a co-activator of the IFNγ-STAT1-BCL6 axis to promote cell proliferation (Camicia et al., 2013). The gene discussed is IFNG; the disease is diffuse large B-cell lymphoma.