NOTCH2 and congenital heart disease: Additionally, a study showed that the hsa-mir-29a-3p and hsa-mir-29b-3p levels in cardiac tissue from patients with congenital heart disease was significantly increased, and the injection of miR-29b-3p into zebrafish embryos induced higher mortality and developmental disorders including cardiac malformation and dysfunction, as well as inhibition of cardiomyocyte proliferation by targeting NOTCH2 (Yang et al., 2020).