Surprisingly, treatment of 6-week-old TazKD mice for 6-weeks with dichloroacetate (DCA; 70 mM in the drinking water), a pyruvate analog that inhibits PDH kinase to prevent inhibitory phosphorylation of PDH, did not alleviate their hypertrophic cardiomyopathy phenotype despite an enhancement of PDH activity (45). This evidence concerns the gene PDP1 and hypertrophic cardiomyopathy.