For instance, several studies demonstrated salvianolic acid A conferred cardio-protective effects as a free radical scavenger through targeting the Akt/GSK-3β, JNK, PI3K/Akt, and ERK1/2 signaling pathways, and reduced myocardial ischemia/reperfusion injury in diabetic rats and cellular hypoxia/reoxygenation injury in in vitro models that involved the reduction cardiomyocytes apoptosis (149–151). Here, AKT1 is linked to myocardial ischemia.