On the other hand, FoxO1 and FoxO3a exerted the same protective effects in H9C2 cells under hyperglycemia as we investigated before (16) and the deficiency of either of them leads to the identical consequences that aggravates meniscus lesions in experimental models through abolishing autophagy and antioxidant defense genes (145), whereas FoxO1 or FoxO3a may have radically different effects in diabetic hearts and they even interfere with each other. The gene discussed is FOXO1; the disease is Hyperglycemia.