In this study, ApoE -/- mice were given AngII at 1,500–2,000ng/kg/min and 0.2% BAPN dissolved in drinking water, resulting in 93%/79%/79% mice developing AAAs/thoracic aneurysms/ruptures over the course of 4 weeks, respectively. This evidence concerns the gene AGT and achalasia-alacrima syndrome.