In this model, an Azlet osmotic pump will be implanted subcutaneously in mice that are susceptible to hypercholesterolemia (e.g., ApoE-/-), providing subcutaneous infusion of angiotensin II at a dose of 500 or 1,000 ng/kg/min for varying durations, ranging from 14 to 28 days. The gene discussed is APOE; the disease is Hypercholesterolemia.