Among them, the upregulated gene BCL2A1 is common in CVD, HTN, obesity, and aging; RNF144B and PTGIS are common in HCL, obesity, aging, and CVD; G0S2, CXCL1, ACKR3, and PTPRD are found in HTN, aging, and CVD; TGFB2, CA12, and MSR1 are familiar in obesity, aging, and CVD. Here, RNF144B is linked to obesity due to melanocortin 4 receptor deficiency.