TNF and obesity due to melanocortin 4 receptor deficiency: We identified 10 major significant hub proteins (FPR2, TNF, CXCL8, CXCL1, IL1B, VEGFA, CYBB, PTGS2, ITGAX, and CCR5) from the PPI network using the cytoHubba plugin where 6 hub proteins are dysregulated for HTN, three for aging, and one for obesity.