PROX1 and diabetes mellitus: Notably, lncRNA-ANRIL was decreased in diabetes and could sponge miR-181a to up-regulate Prox1 and increased ANRIL, or inhibited miR-181a suppressed high glucose (HG) -induced apoptosis of lymphatic endothelial cells (LECs) via caspase pathway, which promoted the lymphatic vessel formation and then accelerated diabetic wound healing (He et al., 2019).