ESAM and Cowden syndrome 1: Regarding antiplatelet therapy throughout hospitalization, both aspirin and P2Y12 receptor antagonists were associated with opposite effects on endothelial cell adhesion molecules, being associated with a significant reduction of S-VCAM-1 at admission in CS patients and with an increase of S-ICAM-1 at admission and days 3–4 in AHF patients (Supplementary Table S1).