ARG1 and Sepsis: The mentioned interplay between pro-inflammatory microglia and iron dyshomeostasis was further confirmed through linear regression analysis curves, which revealed a significant linear relationship between the M1 markers and iron levels during sepsis in the brain (iNOS: r = 0.82; p < 0.0001; iNOS/arg-1: r = 0.84; p < 0.0001) (Figures 10A,B).