AKT1 and sarcopenia: RE can also induce autophagy, which is closely related to sarcopenia (Masiero et al., 2009; Sandri, 2010), by regulating Akt/mechanistic target of rapamycin (mTOR) and Akt/FOXO3a signaling pathways, as well as AMPK-mediated mitochondrial quality control (Zeng et al., 2020).