Susceptibility of SLCO2A1-deficient mice to DSS-induced colitis has been reported, and when macrophages exhibit increased secretion of prostaglandin E2 (PGE2) which could not be imported for further degradation, extracellular prostaglandin signaling gets activated, which consequently leads to inflammasome activation in macrophages (24, 25). This evidence concerns the gene SLCO2A1 and colitis.