Furthermore, the inhibition of endothelial cell prostaglandin extraction and degradation caused by the loss-of-function mutation of SLCO2A1 reinforces the vasodilatory effect of PGE2 (30), which may be responsible for the prominent pathologic findings of lymphangiectasia or angioectasia in parts of our patients with CMUSE. The gene discussed is SLCO2A1; the disease is lymphangiectasis.