MUTYH and breast cancer: Based on all the above, NCCN guidelines for “Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic” (version 2.2022, accessed on March 2022), includes MUTYH mono-allelic variants within the lower penetrance genes that may be added as part of multi-gene testing, but for which the association with BC is still insufficient.