In particular, pathogenic/likely pathogenic variants in six genes were found according to ClinVar database and ACMG/AMP classification using VarSome tool: three of which being in well-established genes associated to breast and/or ovarian cancer (ATM, PALB2 and MSH6) and 3 (MRE11A, MUTYH and RNASEL) being in good candidacy to became susceptibility genes (36). The gene discussed is RNASEL; the disease is ovarian cancer.