The mean values of renal ACE2 were significantly lower in the MetS group than in the control group (0.75 ± 0.08 vs. 4.6 ± 0.62 ng/mL, respectively, P < 0.001), but were significantly higher in MetS + DIZE group rats than in MetS group animals (4.3 ± 0.35 ng/mL, P < 0.001). The gene discussed is ACE2; the disease is metabolic syndrome.