Our study demonstrates that serum E.CPS antibody titer is elevated only in patients with advanced CLD (Child-Pugh B or C), while serum LBP, Mac-2 bp and AAL-Hp levels are elevated not only between investigatory groups (chronic hepatitis and liver cirrhosis) and healthy controls, but between the investigatory groups themselves. This evidence concerns the gene LGALS3 and cirrhosis of liver.