Recently, several biomarkers have been proposed based on the importance of BT in the clinical course of CLD, which include bacterial DNA, soluble CD14, endotoxin and lipopolysaccharide-binding protein (LBP) (5) and the number of potential biomarkers is increasing based on discovery of many mechanisms (6, 7). This evidence concerns the gene LBP and congenital secretory chloride diarrhea 1.