PLOD1 and ovarian hyperstimulation syndrome: While it could be argued that human menopausal gonadotropin (hMG/menotropins) should be superior for OI in clomiphene resistant PCOS women when compared with recombinant FSH preparations (rFSH), due to their erratic background FSH and LH secretion, they can be used interchangeably since a meta-analysis of trials comparing their effects found no difference in ovulation rate, pregnancy rate, multiple pregnancy rate and incidence of ovarian hyperstimulation syndrome (OHSS) (105).