Myo-inositol alone or in combination with D-chiro-inositol has been shown to be beneficial in the management of both the endocrine and metabolic profile of women with PCOS, by improving insulin sensitivity and increasing Sex Hormone Binding Globulin (SHBG), leading to binding of Testosterone and therefore minimizing hyperandrogenic features (33). This evidence concerns the gene SHBG and polycystic ovary syndrome.