In peripheral blood, the percentage of CD3+CD4+HLA-DR+ T cells increased significantly in patients with HL (median, 13.40%, range, 2.90–60.71%) vs. healthy controls (median, 6.25%, range, 4.56–7.45%, Z = 6.065, p < 0.001), and the percentage of CD3+CD8+HLA-DR+ T cells elevated markedly in patients with HL (median, 42.26%, range, 2.60–93.98%) vs. healthy controls (median, 9.08%, range, 4.76–16.20%, Z = 7.211, p < 0.001). Here, CD4 is linked to Hodgkins lymphoma.