Since a variety of DM models has been established in terms of fruit fly, the classic Drosophila Diabetes models will be introduced below, including partial or complete elimination of IPC (type 1 diabetes), knockout of Dilp1-5 gene (type 1 diabetes), insulin signaling pathway mutation (type 2 diabetes), and high-sugar or high-fat inducing (type 2 diabetes) (Figure 2). This evidence concerns the gene INS and type 1 diabetes mellitus.