We have also tested the mRNA expression of apoptosis-relevant genes (BAX, BCL-2 and CASP3) in tumor tissues of our model mice (Fig. 5G), and a TUNEL assay in tissue slices (Fig. 5H), which revealed an elevated apoptosis tendency in FBXO17-overexpressed mice implanted tumor. This evidence concerns the gene CASP3 and neoplasm.