GNRHR and obesity due to melanocortin 4 receptor deficiency: We found that activation of GnRH receptor by diphereline stimulated the proliferation of HPA-s, promoted adipocyte maturation, and increased the formation of lipid droplets in mature adipocytes, indicating that GnRH receptor can mediate the number of preadipocytes and the volume of adipocytes, thus promoting the occurrence of obesity.