Compared with women of normal childbearing age, the incidence of obesity is significantly higher in perimenopausal or menopausal women and patients with central precocious puberty, polycystic ovary syndrome, and long-term treatment of GnRH agonist (GnRHa) 15-18. This evidence concerns the gene GNRH1 and obesity due to melanocortin 4 receptor deficiency.