CCND1 and osteosarcoma: Because cyclin D1 is the downstream target gene of the Wnt/β-catenin signaling pathway and the Wnt/β-catenin signaling pathway has been confirmed to be involved in the malignant biological behavior of osteosarcoma, we detected the key proteins in the Wnt/β-catenin signaling pathway by Western blot analysis, and we found that overexpression of hsa_circ_0087302 affected their expression level.