To elucidate the mechanisms of PAN-induced podocyte injury and the potential effects of DEX on the PTEN/PI3K/Akt signaling pathway, we performed Western blot analysis to measure the protein expression of PI3K p85, Our results showed that the protein expression of the PI3K p85 in the PAN group was lower than that in the control at 8 h and showed a downward trend over time. The gene discussed is AKT1; the disease is polyarteritis nodosa.