NFKB1 and neoplasm: NF-κB inhibits these anti-apoptotic proteins by inducing or upregulating Apoptosis, and it has also been reported that NF-κB can promote the expression of Fas, FasL, DR4, and DR5 and promote apoptosis in some specific cases, but in general, the constitutive activation of NF-κB helps tumor cells to escape apoptosis [59].