Truncation of the C-terminus of LRRC8A as in patients with agammaglobulinemia caused cytoplasmic retention of all LRRC8 subunits, suggesting that the LRRD of LRRC8A is essential to the trafficking of this subunit, and therefore the remaining subunits, to the plasma membrane (Voss et al., 2014). Here, LRRC8A is linked to agammaglobulinemia.