Human astrocytic heterogeneity in the post-mortem human AD brain was also described by Zhou et al. using snRNA-seq analysis in prefrontal cortex samples which showed a down-regulation of genes associated with the metabolic coordination between neurons and astrocytes [e.g., superoxide dismutase 2 (sod2), hypoxia inducible lipid droplet associated (hilpda), fatty acid binding protein 5 (fabp5)] (Zhou et al., 2020). The gene discussed is SOD2; the disease is Alzheimer disease.