PSEN1 and Alzheimer disease: Others found astrocytic engulfment of dystrophic neurites near Aß plaques in the hippocampus of 6 and 12-month-old APP-PS1 male mice and in the medial temporal lobe of patients with AD, further clarifying the phagocytic role of astrocytes that appears conserved across species (Gomez-Arboledas et al., 2018).