APOE and Alzheimer disease: Indeed, using single-nucleus (sn) RNA-seq, Gerrits et al., identified two microglial profiles: AD1–composed of three subclusters enriched for some DAM genes (e.g., LPL, ITGAX, SPP1) (higher abundance found in patients with AD) and AD2–three regrouped microglial subclusters enriched notably in homeostatic genes (higher abundance in healthy control patients) (Gerrits et al., 2021).