APP and Alzheimer disease: Since the initial discovery by Keren-Shaul et al., this particular microglial signature has been uncovered in several other mouse models of AD pathology, including in 9-month-old homozygous APP-KI male and female mice [intercrossing of the heterogenous APPNL–F–G-KI mice, a mouse model with a Swedish, Iberian and Artic mutation in APP (Saito et al., 2014)] (Swartzlander et al., 2018).