WNT10B and irritable bowel syndrome: In this cohort, we identified a novel indel variant that leads to a nonsense allele of WNT10B (c.741delC [p.Cys247∗]); autozygosity of this novel frameshift allele causes a similar SHFM6 phenotype in two unrelated consanguineous Turkish families in our cohort because of IBD (Figures 3A and 3C).