NPR2 and Alzheimer disease: However, a few of the heterozygous missense variant and in-frame deletion alleles of NPR2 were also reported to cause AD epiphyseal chondrodysplasia, Miura type (ECDM; MIM: 615923), characterized by tall stature, arachnodactyly, and long/broad halluces and long metatarsals because of a GoF (potentially a hypermorphic allele) that results in overactivity of guanylate cyclase (Figure S6).65, 66, 67 Genotype-phenotype correlation of these reciprocal traits highlighted their potential underlying etiologies related to abnormal CNP-induced cGMP production.