In contrast to GLI3, similar observational studies of HOXD13 revealed that its disruption was linked to many different digital malformations, including synpolydactyly (SPD1; MIM: 186000), brachydactyly type D (BDD; MIM: 113200), and brachydactyly type E (BDE; MIM: 113300). Here, HOXD13 is linked to synpolydactyly.