The present finding of higher male preponderance has been described previously for non-COVID mucormycosis and CAM (Prakash and Chakrabarti, 2019; Patel et al., 2021; Singh et al., 2021), and is likely due to the fact that testosterone increases expression of glucose regulated protein (GRP78), a stress protein crucial for hyphal invasion by Mucorales spp. This evidence concerns the gene HSPA5 and Zygomycosis.