Recent studies have also shown that tRF3008A suppresses the progression and metastasis of colorectal cancer by destabilizing FOXK1 in an AGO-dependent manner [9], while tRF-3001b aggravates the development of nonalcoholic fatty liver disease by inhibiting autophagy via the same mechanism [44]. Here, FBXW7 is linked to metabolic dysfunction-associated steatotic liver disease.