TRIM65 accelerates colorectal cancer metastasis by targeted degradation of ARHGAP35 protein [15], promotes the invasion of endometrial stromal cells through DUSP6 ubiquitination, activates ERK1/2/C-myc signals [16], and promotes bladder cancer cells through ubiquitination and degradation of ANXA2 invasion [13]. This evidence concerns the gene MAPK3 and urinary bladder cancer.