The mRNA and protein levels of ER stress (Xbp1, sXbp1, Atf4, and Grp78) (Figures 4(e) and 4(i)), senescent (P16 and P21), and SASP (IL6 and Ccl2) markers (Figures 4(f) and 4(i)) and the positive rate of SA-β-gal staining (Figure 4(h)) were lower in the ASCs cocultured with EVs derived from the GW4869-pretreated obesity adipocytes than in the ASCs cocultured with EVs derived from obesity adipocytes. The gene discussed is ATF4; the disease is obesity due to melanocortin 4 receptor deficiency.