CASP1 and ischemic stroke: Another study also found that Tranilast, an NLRP3 inflammasome inhibitor, could promote the polarization of microglia/macrophage from M1 type to M2 type and ameliorate ischemic stroke by inhibiting the NLRP3/caspase-1 pathway in a murine model of distal middle cerebral artery occlusion [57].