RT-qPCR results further depicted reduced expression levels of HDAC8 and SUCNR1 and enhanced IRF1 expression levels in the tumor tissues of mice treated with sh-HDAC8, whereas SUCNR1 expression levels were enhanced, and those of HDAC8 and IRF1 did not change after further oe-SUCNR1 treatment (Figure 6(c)). This evidence concerns the gene HDAC8 and neoplasm.