In addition, the gene relationship network indicated that genes with a correlation coefficient of more than 0.9 were as follows: IRAK3, IL18R1, ATP6V1CA, GYG1, ATP9A, NMT2, ITK, EIF4B, CCND2, CARD11, FBXO21, BLOC1S1, GPR84, LRG1, ANKRD22, FCGR1B (Figure 6C), indicating that the molecular subtypes of sepsis may be the results of multi-gene interactions. This evidence concerns the gene ANKRD22 and Sepsis.