Therefore, we speculated that the interaction of immune response with autophagy, VEGF, oxidative stress, and metabolic pathways may be the major factor leading to the progression of sepsis (Minion and Tewari, 2018; Yin et al., 2019; McBride et al., 2020; Huff et al., 2021). The gene discussed is VEGFA; the disease is Sepsis.