BSG and Alzheimer disease: Besides, we noticed significant changes in SMCs, which decreased from 18.3% of normal tissue to 2.1% of dissection tissue, In our previous study, the expression of Extracellular matrix metalloproteinase inducer (EMMPRIN) in SMCs will significantly affect the progress of AD (Chen et al., 2009), this suggests that SMCs may play an important role in AD and deserves priority attention.