SMC5 and Alzheimer disease: SMC5 is associated to the secretion of inflammatory factors, and macrophage-induced inflammation are critical for aortic dissection (Li et al., 2017), exacerbated inflammation contributes to the formation of AD and eventually leads to the tearing of blood vessels (Lian et al., 2019; Wu et al., 2021),Therefore, SMC5 may play a major role in AD rupture.