ITGA8 mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways (Gaudet et al., 2011), The study of organ injury and fibrosis in rat and mouse models showed that ITGA8 was expressed in vascular SMCs and stromal cells after injury (Nishimura et al., 1991), this suggests that it may play a similar role in the formation of AD. This evidence concerns the gene ITGA8 and Alzheimer disease.