CCN2 and Alzheimer disease: The mutation of ACTA2 is closely related to aortic dissection (Cooper and Brown, 2017; van de Laar et al., 2019).The second key gene IL6, encodes a cytokine that functions in inflammation and the maturation of B cells, the inflammatory mechanism plays a key role in the development and progression of AD (Lu et al., 2021).CTGF, is a Protein Coding gene, and has important pro-inflammatory and pro-fibrotic characteristic (Morales et al., 2018), which play an important role in the progression of AD (Bode-Jänisch et al., 2012; Bersi et al., 2017; Zhao and Bie, 2020).