Extracellular matrix remodeling occurs with the increase of aortic stiffness and the gradual weakening of aortic wall, resulting in AD (Bhushan et al., 2019),Therefore, SMC2 is an early cell in the formation of AD.SMC6 is related to the signal transduction of calcium ions, so we consider it as a signal transduction type SMC. This evidence concerns the gene SMC6 and Alzheimer disease.