THBS1 and malaria: In KEGG enrichment analysis, only three core genes (ITGA8, THBS1, and IL6) were enriched in four signal pathways: “malaria”, “PI3K−Akt signaling pathway”, “ECM−receiver interaction”, and “hypertrophic cardiopathway” (Figure 4E), which imply that these genes play a role in promoting metabolism, growth and angiogenesis in SMCs.