HOGA1 and obesity due to melanocortin 4 receptor deficiency: HOGA1 expression was approximately 1.2-fold higher in samples from individuals with obesity compared with from normal individuals (Wilcoxon rank-sum test p-value = 0.0058) (Figure 2) using RNA sequencing data of 848 adipocyte tissues from The Genotype-Tissue Expression (GTEx) portal (https://gtexportal.org/home/) (GTEx_Consortium, 2017).