Ou et al. identified a specific C5aR1+ neutrophil subpopulation that potentiated BC cell glycolysis through ERK1/2-WTAP-ENO1 signaling, indicating that C5aR1+ neutrophils and the associated WTAP-ENO1 axis contribute to potential BC therapeutic target (Yin et al., 2021). Here, C5AR1 is linked to breast cancer.