SETD2 and non-small cell lung carcinoma: Figure 3C showed a specific example of peak distributions in chromosome 17: 1-6850845. Furthermore, ATAC-seq of TCGA cohorts demonstrated that expression and promoter methylation of SETD2 were associated with chromosomal accessibility in TCGA LUAD (Figures 3D,E). The combined analysis of ATAC-seq and RNA-seq showed that the expression of SETD2 was positively correlated with the openness of the promoter region of the extensive genes in TCGA NSCLC (n = 76, Figures 3F,G).