Previous studies found that SETD2 histological staining scores of tumor cells were linked to good survival in gastric cancer (Chen et al., 2018) and nonmetastatic clear-cell renal cell carcinoma (Liu et al., 2015), possibly because lack of SETD2 increased microsatellite instability and frequency of spontaneous mutations (Liu et al., 2015; Zeng et al., Forthcoming 2022). Here, SETD2 is linked to neoplasm.