According to the heat map (Figure 1A), 15 m6A regulators (YTHDF2, FMR1, METTL3, EIF3A, WTAP, RBM15, VIRMA, IGF2BP2, RBMX, YTHDF1, IGF2BP1, HNRNPA2B1, IGF2BP3, HNRNPC, and LRPPRC) were upregulated, and only 4 regulators (METTL16, METTL14, FTO, and ZC3H13) were downregulated in tumor samples compared to controls. The gene discussed is IGF2BP1; the disease is neoplasm.