FLT3 and acute myeloid leukemia: Tertiary mutations seen in ML-DS most commonly affect genes encoding the cohesin complex, JAK family kinases, and epigenetic regulators; other mutations occur in genes recurrently mutated in other types of AML, including fms-like tyrosine kinase 3 (FLT3) and TP53 (Table 2) (Yoshida et al., 2013; Labuhn et al., 2019; Panferova et al., 2021).