Such mutations are reported in approximately 36–45% of ML-DS samples and affect a range of regulators, including additional sex combs-like 1 (ASXL1), BCL6 corepressor (BCOR), DNMT1, DNMT3A, embryonic ectoderm development (EED), E1A binding protein P300 (EP300), EZH2, KAT8 regulatory NSL complex subunit 1 (KANSL1), lysine demethylase 6A (KDM6A), lysine methyltransferase 2C (KMT2C), N-acetyltransferase 6 (NAT6), SUZ12, and tet methylcytosine dioxygenase 2 (TET2) (Nikolaev et al., 2013; Yoshida et al., 2013; Labuhn et al., 2019; Panferova et al., 2021). Here, EP300 is linked to Dravet syndrome.