CCND1 and nasopharyngeal carcinoma: β-Catenin is high expressed when Wnt/β-catenin signal is aberrantly activated, it activates numerous Wnt pathway downstream proliferation signals, including c-Myc and cyclin D1 and finally accelerates cell cycle, facilitates cell proliferation and migration, which induced to poor diagnosis of NPC (Alamoud and Kukuruzinska, 2018).