Consistent with the highest expression of YAP1 gene in the kidney tissues of advanced stage DKD samples (Figure 6A), YAP1 transcripts were found to be significantly elevated in cultured tubular cells treated with high glucose (Figure 6C), and a greater amount of YAP1 was detected in tubular cells from DKD mice kidney (Figure 6B). Here, YAP1 is linked to diabetic kidney disease.