Besides, using public transcription profiling by array data (GSE142025) including kidney samples from DKD patients and healthy living donor, we for the first time identified five novel hub genes (NFKB1, DYRK2, ATAD2, YAP1, and CHD3) that were significantly linked with the immune status such as NK cells infiltration and validated by Receiver operating characteristic (ROC) curve analysis. This evidence concerns the gene DYRK2 and diabetic kidney disease.