Five genes with a higher degree value, including nuclear factor kappa B subunit 1 (NFKB1), dual specificity tyrosine phosphorylation regulation kinase 2 (DYRK2), ATPase family AAA domain containing 2 (ATAD2), yes-associated protein 1 (YAP1) and chromodomain helicase DNA binding protein 3 (CHD3), were recognized as hub genes that play key roles in the pathogenesis of DKD. The gene discussed is CHD3; the disease is diabetic kidney disease.