Hence, findings from our study precipitates one hypothesis that enhanced YAP1 in renal tubular epithelial cells might produce inflammatory and adherence factors to recruit and activate immune cells, although the mechanism underlying the activity of YAP1-acitvated tubular cells in exaggerating the immune response and boosting DKD development remains to be elucidated yet. This evidence concerns the gene YAP1 and diabetic kidney disease.