DYRK2 and diabetic kidney disease: ROC curves were employed to evaluate the diagnostic value of each hub gene, with the AUC values being 0.976, 0.969, 0.988, 0.925, and 0.733 for NFKB1, DYRK2, ATAD2, YAP1, and CHD3, respectively (Figures 5B–F), confirming the capacity of these hub genes to distinguish DKD from healthy living donors.