YAP1 and diabetic kidney disease: In accordance with our current results showing the robust elevation of YAP1 in both high glucose-treated tubule cells and diabetic mice kidney, enhanced expression and activation of YAP1 were previously observed in renal proximal tubular epithelial cells in diabetic mice model and patients (Chen J. et al., 2020), while inducible YAP1 deletion or pharmacologically inhibition of YAP1 dramatically reduced tubulointerstitial inflammation and fibrosis in DKD mice (Zheng et al., 2021).