Results indicated that CD8A were invariably negatively correlated with MDSCs in most cancer and subtypes, including bladder urothelial carcinoma (BLCA), BRCA, COAD, ESCA, HNSC, KIRC, KIRP, KICH, LUAD, LUSC, mesothelioma (MESO), ovarian serous cystadenocarcinoma (OV), PAAD, metastatic pheochromocytoma and paraganglioma (PCPG), PRAD, READ, SARC, SKCM, stomach adenocarcinoma (STAD), TGCT, THCA, UCEC, and UVM. The gene discussed is CD8A; the disease is pancreatic adenocarcinoma.