CD8A and cancer: T-cell-inflamed phenotype, characterized by elevated type I interferon-related transcriptional profiling accompanied by promigratory chemokines contributing to recruitment of activated CD8+ effector T cells (Trujillo et al., 2018), has become a significant clinical and research interest owing to its close association with better cancer patient survival outcomes (Bruni et al., 2020), and enhanced responses to ICBs (Chen and Mellman, 2017; Gruber et al., 2020).