Thus, we focused on expression levels of CD8A in published single-cell data from five cancer types, including GBM (Patel et al., 2014), LUAD (Kim et al., 2015), BRCA (Chung et al., 2017), retinoblastoma (RB) (Liu et al., 2020), and UVM (Durante et al., 2020), with results illustrating that CD8A was significantly associated with multiple malignant phenotypes and functional states of four cancer types except for LUAD (Figure 8A). This evidence concerns the gene CD8A and retinoblastoma.