The findings revealed that CD8A expression was significantly diminished in varying cancer tissues, including colon adenocarcinoma (COAD), kidney chromophobe cell carcinoma (KICH), liver hepatocellular carcinoma (LIHC), lung squamous cell carcinoma (LUSC), prostate adenocarcinoma (PRAD), rectum adenocarcinoma (READ), and thyroid carcinoma when compared to normal controls (THCA). Here, CD8A is linked to colon adenocarcinoma.