An ASXL1 mutation p.Gly704Arg is present in a family (a 2-year-old child and her 54-year-old paternal uncle, both affected with primary myelofibrosis) included in the study of Andres-Zayas and coworkers on germline predisposition for leukemia (Andrés-Zayas et al., 2021). Here, ASXL1 is linked to leukemia.