Clinical follow-up of SDS patients showed that del(20)(q), without additional clonal chromosomal abnormalities, correlates with a lower risk of developing MDS and/or AML, suggesting that the loss of one copy of EIF6 gene restores ribosome homeostasis in the context of reduced SBDS activity (Valli et al., 2013; Khan et al., 2020; Khan et al., 2021). This evidence concerns the gene SBDS and acute myeloid leukemia.