SBDS and acute myeloid leukemia: Although the risk for developing MDS and AML is not related to the type of SBDS mutations, it can be favorably modified by other genetic factors as the presence of specific chromosomal abnormalities, in particular, the i(7)(q10) and del(20)(q) if they are the only abnormality present (Minelli et al., 2009; Khan et al., 2021).