It is interesting to mention that of these identified hub genes, the three hub genes RPS5 (encodes ribosomal protein S5), RPL37A (encodes ribosomal protein 37A), and RPLP0 (encodes ribosomal protein lateral stalk subunit P0), till date, have not been reported to show correlation to CKD. Here, RPLP0 is linked to chronic kidney disease.