AKT1 and cancer: Among these modules, the green module (r = 0.5, P = 6e−17), the black module (r = 0.6, P = 5e−26), and the brown module (r = 0.66, P = 8e−32) exhibited the highest correlation with the hypoxia score and was considered the “hypoxia-related module.” Finally, we obtained 831 hypoxia-related genes and found that they are significantly enriched in cancer-related pathways, such as pathways in cancer, PI3K-Akt signaling pathway, phagosome, transcriptional mis-regulation in cancer, and proteoglycans in cancer.