The novel freckles-associated variant rs35415928 in SPATA33 serves as a strong eQTL for several genes in both skin tissue (sun-exposed and no-sun-exposed) and fibroblasts, showing the strongest association with DBNDD1 (Supplementary Figure S7), a gene involved in tanning ability (Nan et al., 2009) and squamous cell carcinoma (Asgari et al., 2016). Here, SPATA33 is linked to squamous cell carcinoma.