Moreover, up-regulation of TOPIMT expression was significantly associated with low OS in ACC, CESC, DLBC, KICH, LAML, MESO, OV, SARC, THYM, and UVM cancer tissues; whereas high TOP1MT expression was significantly associated with high prognosis in DLBC and THYM cancer tissues (Supplementary Figure S2A). Here, TOP1MT is linked to cancer.